Relationship between cytomegalovirus seropositivity and risk of multiple sclerosis

Takeaway

  • Cytomegalovirus (CMV) seropositivity is associated with reduced risk of multiple sclerosis (MS) development, and those who are CMV seronegative but seropositive for Epstein Barr Virus (EBV) or human herpesvirus 6A (HHV-6A) are at increased risk of MS development.

Why this matters

    It has been established that EBV is a risk factor for MS, and HHV-6A also appears to be associated with increased MS risk, but understanding of the relationship between CMV and MS development is unclear. This study demonstrated that CMV seropositivity leads to reduced MS risk and has implications for future treatment direction.