Metabolic responses to SOD1G93A mutations in mice models of amyotrophic lateral sclerosis

Takeaway

• Metabolic responses to SOD1G93A expression occur in the thoracic spinal cord prior to visible symptom onset in mice models of amyotrophic lateral sclerosis (ALS)

Why this matters

Gaining further understanding of the early metabolic responses to SOD1G93A mutations in ALS-associated genes may highlight therapeutic opportunity to maintain motor neuron viability in people with ALS.